Carbohydrate import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Carbohydrate import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRRAP, SON, and KDM1A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate import across plasma membrane activity versus TRRAP in LSCC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRRAP →	-0.231	-0.087	<.001	<.001	3	7
LUAD	SON →	-0.125	-0.097	.001	<.001	3	7
GBM	KDM1A →	-0.269	-0.113	<.001	<.001	3	7
OV	DHX9 →	-0.246	-0.097	<.001	<.001	3	6
OV	LOX →	+0.864	+0.073	<.001	.004	3	6
HNSC	NUCB1_S369 →	+0.610	+0.107	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098704 vs TRRAP — LSCC

Explore this scatter interactively →