Carbohydrate import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Carbohydrate import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A1, PLOD2, and ENO2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate import across plasma membrane activity versus SLC2A1 in LSCC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC2A1 →	+1.279	+0.653	<.001	<.001	3	5
UCEC	PLOD2 →	+0.900	+0.753	<.001	.004	3	5
UCEC	ENO2 →	+1.093	+0.772	.003	.003	3	5
LUAD	OR7E7P →	-0.794	-0.575	<.001	<.001	3	5
PDAC	ERO1A →	+0.950	+0.826	<.001	<.001	3	5
OV	SETMAR →	-0.529	-0.641	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098704 vs SLC2A1 — LSCC

Explore this scatter interactively →