Carbohydrate import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Carbohydrate import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A1, NIBAN2, and ITGA3, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate import across plasma membrane activity versus SLC2A1 in LIVER (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SLC2A1 →	+2.626	+1.571	.002	.003	3	11
LIVER	NIBAN2 →	+2.469	+2.122	<.001	<.001	3	5
LIVER	ITGA3 →	+5.659	+1.681	<.001	.002	3	5
BLOOD_Lymphoma	SETMAR →	-0.614	-0.762	.009	.004	3	4
LIVER	SLC25A15 →	-1.426	-1.562	.001	.002	2	5
LIVER	NR1H2 →	+0.847	+1.687	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098704 vs SLC2A1 — LIVER

Explore this scatter interactively →