Neurotransmitter loading into synaptic vesicle

Across TCGA cell cohorts, RNA activity of the Neurotransmitter loading into synaptic vesicle pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF3R, PDE5A, and CD226, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CSF3R grouped by Neurotransmitter loading into synaptic vesicle-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CSF3R →	+0.337	+1.925	.003	<.001	3	4
OESOPHAGUS	PDE5A →	+0.090	+1.122	<.001	.007	3	4
UPPER_AERODIGESTIVE_TRACT	CD226 →	+0.146	+1.339	.005	.002	3	4
SOFT_TISSUE	FKBP7 →	+0.300	+1.602	<.001	.001	3	4
SOFT_TISSUE	SOS2 →	+0.183	+1.493	.001	.004	3	4
SOFT_TISSUE	SETBP1 →	-0.318	-1.802	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CSF3R by Neurotransmitter loading into synaptic vesicle activity — BLOOD_Myeloma

Explore this box plot interactively →