Postsynaptic specialization assembly

Across TCGA patient cohorts, RNA activity of the Postsynaptic specialization assembly pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYCT1, S1PR1, and CNRIP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic specialization assembly activity versus MYCT1 in CCRCC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MYCT1 →	+0.893	+0.903	<.001	<.001	3	9
CCRCC	S1PR1 →	+0.816	+0.886	<.001	<.001	3	8
BRCA	CNRIP1 →	+0.609	+0.472	.004	.005	3	7
COAD	SPARCL1 →	+1.273	+0.404	<.001	<.001	3	7
CCRCC	EMCN →	+1.327	+0.940	<.001	<.001	3	7
CCRCC	CLEC14A →	+0.999	+0.822	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098698 vs MYCT1 — CCRCC

Explore this scatter interactively →