Postsynaptic specialization assembly

Across TCGA cell cohorts, RNA activity of the Postsynaptic specialization assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO1F, PILRA, and EPB41L1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic specialization assembly activity versus MYO1F in LUNG_SCLC (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MYO1F →	+0.255	+0.246	.006	.005	3	2
LUNG_NSCLC_LUAD	PILRA →	+1.356	+2.007	.004	<.001	3	2
STOMACH	EPB41L1 →	-3.761	-2.258	.006	.002	2	3
LUNG_NSCLC_LUAD	MYLK2 →	-0.473	-1.967	.005	<.001	3	2
LUNG_NSCLC_LUAD	FBXL16 →	+1.776	+1.920	.002	<.001	3	2
LUNG_NSCLC_LUAD	FEZ2 →	-0.756	-2.045	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098698 vs MYO1F — LUNG_SCLC

Explore this scatter interactively →