Regulation of synaptic vesicle cycle

Across TCGA cell cohorts, RNA activity of the Regulation of synaptic vesicle cycle pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VDAC3, EML6, and NOC2L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VDAC3 grouped by Regulation of synaptic vesicle cycle-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	VDAC3 →	+0.911	+1.226	.003	.004	3	4
BLOOD_Lymphoma	EML6 →	-2.877	-1.473	<.001	<.001	3	4
LUNG_NSCLC_LUSC	NOC2L →	-1.224	-1.500	<.001	.004	3	4
PANCREAS	ADGRB2 →	-1.746	-1.134	<.001	.006	3	4
BLOOD_Lymphoma	TM7SF2 →	-1.180	-1.479	.007	<.001	2	5
SOFT_TISSUE	NDUFC2 →	+0.783	+1.186	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VDAC3 by Regulation of synaptic vesicle cycle activity — OESOPHAGUS

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