G protein-coupled serotonin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the G protein-coupled serotonin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFC5, PPIH, and SDC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RFC5 grouped by G protein-coupled serotonin receptor signaling pathway-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RFC5 →	+0.791	+0.979	<.001	.002	2	5
LUNG_SCLC	PPIH →	+0.839	+0.877	.004	.009	3	4
KIDNEY	SDC3 →	+1.365	+1.059	.007	.007	3	4
LIVER	CNTNAP3C →	+1.256	+0.817	.003	.007	2	4
LUNG_NSCLC_LUSC	NDUFC1 →	+0.801	+0.224	.003	.005	2	4
BLOOD_Leukemia	IPP →	+0.871	+1.226	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RFC5 by G protein-coupled serotonin receptor signaling pathway activity — LARGE_INTESTINE

Explore this box plot interactively →