Inorganic anion transmembrane transport

pathway activity — cross-omics
GO:0098661Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Inorganic anion transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCP2, TST, and HSD17B4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCSCP2 →+0.271+0.039<.001<.00135
PDACTST →+0.567+0.035<.001<.00135
PDACHSD17B4 →+0.191+0.025.004.00235
GBMUSP20_S333 →+0.293+0.047.009.00135
GBMHNRNPDL →-0.217-0.054<.001<.00135
LUADSPATS2 →-0.339-0.043<.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration