Inorganic anion transmembrane transport

pathway activity — cross-omics
GO:0098661Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Inorganic anion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYPN, CR2, and ARHGAP32, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMMYPN →+0.096+0.200.008.00334
PDACCR2 →-1.544-0.624.002.00625
HNSCARHGAP32 →+0.422+0.312.009.00134
HNSCMAL2 →+0.887+0.254<.001<.00134
GBMCDS1 →+0.869+0.268.003<.00134
UCECTRAV26-1 →-0.595-0.861.008<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration