Learned vocalization behavior or vocal learning

Across TCGA patient cohorts, RNA activity of the Learned vocalization behavior or vocal learning pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OSTF1, SEPTIN7, and SH3BGRL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Learned vocalization behavior or vocal learning activity versus OSTF1 in GBM (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	OSTF1 →	-0.374	-0.094	<.001	.001	3	5
GBM	SEPTIN7 →	+0.337	+0.144	<.001	<.001	3	4
GBM	SH3BGRL3 →	-0.331	-0.129	<.001	<.001	3	4
GBM	SNAP23 →	-0.306	-0.111	<.001	<.001	3	4
GBM	TNFAIP8 →	-0.823	-0.098	<.001	<.001	3	4
CCRCC	TRAF3IP3 →	-0.510	-0.107	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098598 vs OSTF1 — GBM

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