Learned vocalization behavior or vocal learning

Across TCGA cell cohorts, RNA activity of the Learned vocalization behavior or vocal learning pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRXN2, NEUROG1, and HTT, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NRXN2 grouped by Learned vocalization behavior or vocal learning-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NRXN2 →	-0.209	-0.933	<.001	<.001	3	8
BLOOD_Leukemia	NEUROG1 →	-0.276	-0.847	<.001	.009	3	6
BREAST	HTT →	-0.270	-0.913	<.001	<.001	3	6
KIDNEY	SCRT1 →	-0.278	-1.697	<.001	.002	3	5
KIDNEY	MCM6 →	-0.276	-1.200	.008	.007	3	4
LARGE_INTESTINE	PRSS21 →	-0.255	-0.742	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NRXN2 by Learned vocalization behavior or vocal learning activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →