Learned vocalization behavior or vocal learning

Across TCGA cell cohorts, RNA activity of the Learned vocalization behavior or vocal learning pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HTT, STRA6, and CTBP1, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Learned vocalization behavior or vocal learning activity versus HTT in KIDNEY (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	HTT →	+1.165	+1.254	<.001	.002	3	15
SKIN	STRA6 →	+3.356	+0.663	<.001	<.001	3	11
SKIN	CTBP1 →	+0.825	+0.696	.002	.003	3	9
SKIN	CCDC33 →	+1.888	+0.657	<.001	.001	2	9
LIVER	TNIP2 →	+0.553	+0.673	<.001	.006	3	8
CNS	GAK →	+0.497	+0.730	.004	.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098598 vs HTT — KIDNEY

Explore this scatter interactively →