Observational learning

Across TCGA patient cohorts, RNA activity of the Observational learning pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CTNND2_S474, PLIN3, and TRIM21, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Observational learning activity versus CTNND2_S474 in LUAD (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CTNND2_S474 →	+0.715	+0.085	.005	<.001	3	5
GBM	PLIN3 →	-0.425	-0.149	<.001	<.001	3	5
HNSC	TRIM21 →	-0.423	-0.084	<.001	<.001	3	4
HNSC	CD8A →	-0.365	-0.074	<.001	<.001	3	4
GBM	DOK2 →	-0.707	-0.116	<.001	<.001	3	4
HNSC	GBP1 →	-0.597	-0.080	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098597 vs CTNND2_S474 — LUAD

Explore this scatter interactively →