Observational learning

Across TCGA cell cohorts, RNA activity of the Observational learning pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEURL2, STRA6, and ABHD11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEURL2 grouped by Observational learning-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NEURL2 →	-0.884	-1.106	.003	.001	3	4
LARGE_INTESTINE	STRA6 →	-1.456	-0.751	.007	.002	3	4
KIDNEY	ABHD11 →	+1.391	+1.635	.001	<.001	3	4
LIVER	TTLL1 →	-1.368	-1.531	.001	<.001	3	3
LIVER	PWWP3A →	-1.002	-1.903	.002	<.001	3	3
LIVER	TOLLIP →	-0.709	-1.518	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEURL2 by Observational learning activity — LARGE_INTESTINE

Explore this box plot interactively →