Cellular response to virus

Across TCGA patient cohorts, RNA activity of the Cellular response to virus pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADA2, IFI35, and IL16, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to virus activity versus ADA2 in CCRCC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ADA2 →	+0.525	+0.038	<.001	<.001	3	10
LSCC	IFI35 →	+0.549	+0.062	<.001	<.001	3	9
GBM	IL16 →	+0.708	+0.098	<.001	<.001	3	9
GBM	LCP2 →	+0.559	+0.086	<.001	<.001	3	9
GBM	OAS2 →	+0.834	+0.076	<.001	<.001	3	9
GBM	ARHGAP45 →	+0.671	+0.096	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098586 vs ADA2 — CCRCC

Explore this scatter interactively →