Cellular response to virus

Across TCGA cell cohorts, RNA activity of the Cellular response to virus pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLT3LG, SSX1, and TRIM54, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FLT3LG grouped by Cellular response to virus-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FLT3LG →	+0.146	+0.129	<.001	<.001	3	4
LUNG_SCLC	SSX1 →	+0.145	+0.122	.009	.003	3	4
LUNG_SCLC	TRIM54 →	-0.159	-0.097	<.001	<.001	3	4
LARGE_INTESTINE	MCHR2 →	+0.107	+0.072	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ADCY4 →	-0.181	-0.079	<.001	<.001	3	4
OVARY	KIAA0100 →	+0.351	+0.104	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FLT3LG by Cellular response to virus activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →