Cellular response to virus

Across TCGA cell cohorts, RNA activity of the Cellular response to virus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRP1B, PUS7, and ANKRD13B, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to virus activity versus RRP1B in LUNG_SCLC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RRP1B →	+0.894	+0.249	<.001	.005	3	10
BLOOD_Lymphoma	PUS7 →	+0.854	+0.162	.002	<.001	3	8
STOMACH	ANKRD13B →	+2.090	+0.340	.003	.001	3	8
CNS	CCT8 →	+0.557	+0.245	<.001	<.001	3	7
OVARY	HNRNPA1 →	+0.971	+0.294	.003	<.001	3	7
LIVER	PAM16 →	+0.450	+0.193	.004	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098586 vs RRP1B — LUNG_SCLC

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