Sperm motility

Across TCGA cell cohorts, RNA activity of the Sperm motility pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCG, ZNF687, and PRPF38A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GCG grouped by Sperm motility-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GCG →	+0.120	+0.197	.002	.001	3	6
BREAST	ZNF687 →	-0.883	-0.113	<.001	.004	3	6
BONE	PRPF38A →	-0.878	-0.379	.007	.002	3	5
BONE	CHTOP →	-0.663	-0.396	<.001	.003	3	5
LIVER	PARS2 →	-0.490	-0.164	.001	<.001	3	5
BLOOD_Leukemia	RPRD2 →	-0.868	-0.320	.005	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GCG by Sperm motility activity — CNS

Explore this box plot interactively →