Sperm motility

Across TCGA cell cohorts, RNA activity of the Sperm motility pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR76, DTD2, and KHSRP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm motility activity versus WDR76 in BLOOD_Myeloma (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	WDR76 →	+1.621	+0.208	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	DTD2 →	+1.084	+0.582	.008	<.001	3	6
BLOOD_Myeloma	KHSRP →	+0.493	+0.177	.009	.001	3	6
PANCREAS	BCLAF1 →	+0.565	+0.267	.004	.005	3	5
UPPER_AERODIGESTIVE_TRACT	FAM98B →	+1.102	+0.620	<.001	<.001	3	5
STOMACH	ATP5F1D →	+0.881	+0.294	.004	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097722 vs WDR76 — BLOOD_Myeloma

Explore this scatter interactively →