Cell surface receptor signaling pathway via STAT

Across TCGA patient cohorts, RNA activity of the Cell surface receptor signaling pathway via STAT pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPN, LCP1, and ARHGAP30, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell surface receptor signaling pathway via STAT activity versus SPN in OV (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SPN →	+0.634	+0.033	<.001	<.001	3	10
GBM	LCP1 →	+1.029	+0.072	<.001	<.001	3	10
GBM	ARHGAP30 →	+0.726	+0.067	<.001	<.001	3	10
GBM	SASH3 →	+0.551	+0.068	<.001	<.001	3	10
UCEC	DOCK10 →	+0.453	+0.048	<.001	<.001	3	10
GBM	DOK2 →	+0.631	+0.057	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097696 vs SPN — OV

Explore this scatter interactively →