Cell surface receptor signaling pathway via STAT

Across TCGA patient cohorts, RNA activity of the Cell surface receptor signaling pathway via STAT pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR1B, TNFSF14, and CD72, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell surface receptor signaling pathway via STAT activity versus FCGR1B in GBM (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FCGR1B →	+0.822	+0.142	<.001	.002	3	7
GBM	TNFSF14 →	+0.844	+0.100	<.001	<.001	3	6
BRCA	CD72 →	+0.725	+0.170	<.001	.001	3	6
GBM	BCL2A1 →	+1.810	+0.179	<.001	<.001	3	6
GBM	ITGAX →	+0.738	+0.106	<.001	<.001	3	6
GBM	ROBO2 →	-1.712	-0.158	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097696 vs FCGR1B — GBM

Explore this scatter interactively →