Cell surface receptor signaling pathway via STAT

Across TCGA cell cohorts, RNA activity of the Cell surface receptor signaling pathway via STAT pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSRA, RALGPS2, and RPL5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MSRA grouped by Cell surface receptor signaling pathway via STAT-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MSRA →	-2.360	-1.306	<.001	<.001	3	4
OESOPHAGUS	RALGPS2 →	+1.706	+1.105	<.001	.003	3	3
OESOPHAGUS	RPL5 →	+0.859	+0.960	.003	.002	3	3
LUNG_NSCLC_LUAD	CCL20 →	-2.195	-0.741	.009	<.001	3	3
LUNG_NSCLC_LUAD	RNF126 →	-0.367	-0.422	.006	.009	3	3
BLOOD_Myeloma	ELMO3 →	-0.454	-1.175	.003	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MSRA by Cell surface receptor signaling pathway via STAT activity — BLOOD_Myeloma

Explore this box plot interactively →