Cell surface receptor signaling pathway via STAT

Across TCGA cell cohorts, RNA activity of the Cell surface receptor signaling pathway via STAT pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED7, CHRNE, and CLN5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMED7 grouped by Cell surface receptor signaling pathway via STAT-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TMED7 →	-0.499	-1.967	<.001	<.001	3	3
BLOOD_Myeloma	CHRNE →	-0.270	-0.383	.003	.006	2	4
LUNG_NSCLC_LUSC	CLN5 →	-0.252	-0.393	<.001	.001	3	3
LARGE_INTESTINE	AKR1A1 →	+0.232	+0.308	.002	<.001	3	3
LARGE_INTESTINE	FLG2 →	-0.114	-0.296	.003	<.001	3	3
BLOOD_Lymphoma	USP9Y →	+0.250	+2.067	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMED7 by Cell surface receptor signaling pathway via STAT activity — KIDNEY

Explore this box plot interactively →