Double-strand break repair via classical nonhomologous end joining

Across TCGA patient cohorts, RNA activity of the Double-strand break repair via classical nonhomologous end joining pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MTX3, BMPR2_S681, and IRS1_S636, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Double-strand break repair via classical nonhomologous end joining activity versus MTX3 in LUAD (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MTX3 →	+0.294	+0.030	<.001	<.001	3	5
OV	BMPR2_S681 →	+0.651	+0.037	<.001	.004	3	4
CCRCC	IRS1_S636 →	+0.913	+0.031	.003	.002	3	4
BRCA	C5AR1_S327 →	-0.830	-0.036	<.001	<.001	3	4
LUAD	NDUFAF2 →	+0.303	+0.026	<.001	<.001	3	4
GBM	TLR2 →	-0.402	-0.030	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097680 vs MTX3 — LUAD

Explore this scatter interactively →