Double-strand break repair via classical nonhomologous end joining

Across TCGA patient cohorts, RNA activity of the Double-strand break repair via classical nonhomologous end joining pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM66C, DNM3, and SHROOM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Double-strand break repair via classical nonhomologous end joining activity versus FAM66C in GBM (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FAM66C →	-0.654	-0.776	<.001	<.001	3	5
OV	DNM3 →	-0.476	-0.474	.001	.009	3	4
GBM	SHROOM2 →	-0.768	-0.788	.008	<.001	3	4
UCEC	REEP1 →	-0.620	-0.474	.006	.008	3	3
HNSC	ENDOV →	-0.441	-0.552	.001	.004	3	3
HNSC	PLAAT3 →	-0.741	-0.418	.009	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097680 vs FAM66C — GBM

Explore this scatter interactively →