Double-strand break repair via classical nonhomologous end joining

Across TCGA cell cohorts, RNA activity of the Double-strand break repair via classical nonhomologous end joining pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAF1, LMAN2L, and C6orf136, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRAF1 grouped by Double-strand break repair via classical nonhomologous end joining-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TRAF1 →	+0.801	+0.213	.004	.006	3	4
OVARY	LMAN2L →	-0.586	-0.213	.004	.004	2	5
OVARY	C6orf136 →	+0.715	+0.281	.004	<.001	3	4
LIVER	PKD1 →	-1.000	-0.373	.005	.009	3	4
PANCREAS	SCAI →	-0.596	-0.204	<.001	.004	3	3
KIDNEY	CCT6B →	-0.665	-0.297	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRAF1 by Double-strand break repair via classical nonhomologous end joining activity — BREAST

Explore this box plot interactively →