Double-strand break repair via classical nonhomologous end joining

Across TCGA cell cohorts, RNA activity of the Double-strand break repair via classical nonhomologous end joining pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAT3, CD55, and HSD17B14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Double-strand break repair via classical nonhomologous end joining activity versus ADAT3 in STOMACH (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ADAT3 →	+1.176	+0.232	.005	.002	3	5
CNS	CD55 →	-1.406	-0.152	.009	.003	3	4
LARGE_INTESTINE	HSD17B14 →	+0.804	+0.138	.004	.002	3	4
LUNG_NSCLC_LUAD	ANLN →	-0.607	-0.148	.001	.004	3	4
SOFT_TISSUE	ITGA6 →	-2.309	-0.222	.005	.002	3	3
LUNG_SCLC	FLYWCH2 →	+0.900	+0.273	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097680 vs ADAT3 — STOMACH

Explore this scatter interactively →