Amylin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Amylin receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGA7, KANK3, and RASIP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amylin receptor signaling pathway activity versus ITGA7 in PDAC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ITGA7 →	+0.610	+0.099	<.001	<.001	3	8
CCRCC	KANK3 →	+0.456	+0.091	<.001	<.001	3	8
COAD	RASIP1 →	+0.582	+0.111	.002	<.001	3	8
GBM	TPM2 →	+0.894	+0.125	<.001	<.001	3	8
OV	ALYREF →	-0.521	-0.090	<.001	<.001	3	8
OV	NDC1 →	-0.356	-0.087	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097647 vs ITGA7 — PDAC

Explore this scatter interactively →