Calcitonin family receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Calcitonin family receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYCT1, CALCRL, and EMCN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcitonin family receptor signaling pathway activity versus MYCT1 in CCRCC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MYCT1 →	+1.599	+0.828	<.001	<.001	3	6
OV	CALCRL →	+1.909	+0.414	.004	<.001	3	6
CCRCC	EMCN →	+2.494	+0.850	<.001	<.001	3	5
CCRCC	RGCC →	+1.185	+0.497	<.001	.004	3	5
CCRCC	CD93 →	+0.678	+0.691	<.001	<.001	3	5
CCRCC	RAMP2 →	+0.781	+0.458	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097646 vs MYCT1 — CCRCC

Explore this scatter interactively →