L-arginine import across plasma membrane

Across TCGA patient cohorts, RNA activity of the L-arginine import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCEAL4, XRCC6P2, and PTGER4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-arginine import across plasma membrane activity versus TCEAL4 in CCRCC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TCEAL4 →	-0.306	-0.597	.006	.006	3	4
CCRCC	XRCC6P2 →	+0.208	+0.459	<.001	.009	3	4
HNSC	PTGER4 →	-1.246	-0.209	.002	.002	3	4
BRCA	FPR3 →	-0.589	-0.537	.001	.001	3	4
LUAD	SAMHD1 →	-0.672	-0.315	<.001	.001	3	4
UCEC	LEF1-AS1 →	+0.749	+0.480	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097638 vs TCEAL4 — CCRCC

Explore this scatter interactively →