L-arginine import across plasma membrane

Across TCGA cell cohorts, RNA activity of the L-arginine import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF3G, LRG1, and TNIP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF3G grouped by L-arginine import across plasma membrane-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	EIF3G →	-0.526	-1.034	.003	<.001	2	5
BLOOD_Lymphoma	LRG1 →	+2.263	+2.033	.006	<.001	3	4
SOFT_TISSUE	TNIP2 →	-0.754	-1.794	.006	.001	3	4
BLOOD_Lymphoma	ANO9 →	+1.812	+2.033	.005	<.001	3	4
LUNG_NSCLC_LUAD	GPR161 →	-1.035	-0.735	<.001	.003	3	3
LUNG_NSCLC_LUSC	SNX21 →	-1.700	-1.274	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF3G by L-arginine import across plasma membrane activity — BREAST

Explore this box plot interactively →