L-arginine import across plasma membrane

Across TCGA cell cohorts, RNA activity of the L-arginine import across plasma membrane pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNPO, CRP, and FGD4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PNPO grouped by L-arginine import across plasma membrane-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PNPO →	-0.393	-0.454	<.001	<.001	3	4
LARGE_INTESTINE	CRP →	-0.189	-0.311	.004	.003	3	4
LUNG_NSCLC_LUSC	FGD4 →	-0.270	-0.272	.004	<.001	3	3
LARGE_INTESTINE	RAB14 →	-0.191	-0.305	.007	<.001	3	3
SOFT_TISSUE	KIR2DL3 →	-0.264	-0.240	<.001	.001	3	3
LIVER	VKORC1L1 →	+0.405	+0.367	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PNPO by L-arginine import across plasma membrane activity — LARGE_INTESTINE

Explore this box plot interactively →