L-arginine import across plasma membrane

Across TCGA cell cohorts, RNA activity of the L-arginine import across plasma membrane pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRA1, FIG4, and PRLR, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LILRA1 grouped by L-arginine import across plasma membrane-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LILRA1 →	+0.220	+1.609	.007	.002	2	1
OVARY	FIG4 →	+0.135	+1.609	.003	.002	2	1
OVARY	PRLR →	+0.316	+1.609	.003	.002	2	1
OVARY	GNA13 →	+0.258	+1.609	.003	.002	2	1
OVARY	SMAD9 →	+0.163	+1.609	.006	.002	2	1
OVARY	AGT →	+0.538	+1.609	.009	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LILRA1 by L-arginine import across plasma membrane activity — OVARY

Explore this box plot interactively →