Potassium ion export across plasma membrane

Across TCGA patient cohorts, RNA activity of the Potassium ion export across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDAH1, TPPP3, and UTP4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Potassium ion export across plasma membrane activity versus DDAH1 in BRCA (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDAH1 →	+0.670	+0.056	<.001	<.001	3	7
UCEC	TPPP3 →	+1.146	+0.047	<.001	.008	3	6
BRCA	UTP4 →	-0.331	-0.048	<.001	<.001	3	6
BRCA	DEPTOR →	+0.262	+0.029	.009	.004	3	6
LSCC	MPHOSPH10 →	-0.273	-0.043	<.001	<.001	3	6
LUAD	RNF180_S230 →	+0.864	+0.077	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097623 vs DDAH1 — BRCA

Explore this scatter interactively →