Potassium ion export across plasma membrane

Across TCGA patient cohorts, RNA activity of the Potassium ion export across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGFR3, UBQLN1, and PDE12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Potassium ion export across plasma membrane activity versus FGFR3 in GBM (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FGFR3 →	+1.459	+0.260	<.001	<.001	3	4
CCRCC	UBQLN1 →	-0.175	-0.415	<.001	.001	3	3
CCRCC	PDE12 →	-0.217	-0.517	<.001	.001	3	3
GBM	LINC00844 →	+0.836	+0.257	<.001	<.001	3	3
GBM	TMEM214 →	-0.250	-0.246	.001	.003	3	3
LSCC	PRR3 →	-0.366	-0.355	.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097623 vs FGFR3 — GBM

Explore this scatter interactively →