Potassium ion export across plasma membrane

Across TCGA cell cohorts, RNA activity of the Potassium ion export across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEX7, MXRA7, and ERI2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PEX7 grouped by Potassium ion export across plasma membrane-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PEX7 →	+0.887	+1.323	.001	<.001	3	4
STOMACH	MXRA7 →	-2.134	-0.883	.006	.004	2	5
STOMACH	ERI2 →	+0.554	+1.199	.004	<.001	3	4
LARGE_INTESTINE	COMMD8 →	+0.532	+0.896	.002	.004	3	4
BREAST	ZNF14 →	+0.620	+0.721	.004	.009	3	4
SOFT_TISSUE	CTNNAL1 →	-1.319	-0.837	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PEX7 by Potassium ion export across plasma membrane activity — PANCREAS

Explore this box plot interactively →