Potassium ion export across plasma membrane

Across TCGA cell cohorts, RNA activity of the Potassium ion export across plasma membrane pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPIF, ATP5F1E, and FAM104B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPIF grouped by Potassium ion export across plasma membrane-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PPIF →	-0.329	-2.126	.002	<.001	3	4
BREAST	ATP5F1E →	-0.223	-1.066	.002	.005	3	4
BREAST	FAM104B →	+0.124	+1.011	.009	.005	3	4
STOMACH	IGDCC4 →	+0.324	+1.490	<.001	.001	3	4
LARGE_INTESTINE	SMARCD2 →	+0.123	+0.771	.007	.003	3	4
OVARY	C1orf74 →	+0.122	+1.009	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPIF by Potassium ion export across plasma membrane activity — PANCREAS

Explore this box plot interactively →