Lamellipodium organization

Across TCGA patient cohorts, RNA activity of the Lamellipodium organization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLIC2, F13A1, and FAM126A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lamellipodium organization activity versus CLIC2 in HNSC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CLIC2 →	+0.623	+0.047	<.001	.008	3	8
CCRCC	F13A1 →	+0.584	+0.028	<.001	<.001	3	8
BRCA	FAM126A →	+0.237	+0.022	<.001	<.001	3	8
LSCC	LMCD1 →	+0.416	+0.038	<.001	<.001	3	8
HNSC	SERBP1 →	-0.281	-0.064	<.001	<.001	3	8
LSCC	PPM1F →	+0.207	+0.036	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097581 vs CLIC2 — HNSC

Explore this scatter interactively →