Lamellipodium organization

Across TCGA patient cohorts, RNA activity of the Lamellipodium organization pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPATA17, CNRIP1, and CDKN2B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lamellipodium organization activity versus SPATA17 in OV (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SPATA17 →	-0.995	-0.210	.001	.001	3	3
CCRCC	CNRIP1 →	+0.794	+0.159	.001	.008	3	3
CCRCC	CDKN2B →	+0.603	+0.183	.001	<.001	3	3
CCRCC	VEGFC →	+1.128	+0.169	.001	.002	3	3
BRCA	DDR2 →	+1.005	+0.242	.006	.002	3	3
CCRCC	CAVIN1 →	+0.662	+0.158	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097581 vs SPATA17 — OV

Explore this scatter interactively →