Lamellipodium organization

Across TCGA cell cohorts, RNA activity of the Lamellipodium organization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THBS1, IKBKE, and TACSTD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, THBS1 grouped by Lamellipodium organization-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	THBS1 →	+2.392	+1.011	.006	.006	3	5
LUNG_NSCLC_LUSC	IKBKE →	+2.058	+1.545	.008	<.001	3	5
LUNG_NSCLC_LUSC	TACSTD2 →	+4.239	+1.252	<.001	<.001	3	5
SOFT_TISSUE	FBXO10 →	-1.406	-1.917	.009	<.001	3	5
LUNG_SCLC	FARP2 →	-0.782	-1.101	.006	.009	3	5
OVARY	ATP5F1E →	+0.672	+0.957	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

THBS1 by Lamellipodium organization activity — PANCREAS

Explore this box plot interactively →