Lamellipodium organization

Across TCGA cell cohorts, RNA activity of the Lamellipodium organization pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM156B, STIM2, and P3H2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lamellipodium organization activity versus FAM156B in SOFT_TISSUE (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FAM156B →	-0.961	-0.262	.006	.006	3	5
LUNG_NSCLC_LUAD	STIM2 →	-0.713	-0.175	<.001	.001	3	4
SOFT_TISSUE	P3H2 →	+4.054	+0.307	<.001	.002	3	4
SOFT_TISSUE	MYPOP →	-0.642	-0.252	<.001	<.001	3	4
LUNG_NSCLC_LUSC	ZBTB32 →	-0.302	-0.307	.006	.006	3	3
LUNG_NSCLC_LUAD	ZNF513 →	-0.827	-0.167	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097581 vs FAM156B — SOFT_TISSUE

Explore this scatter interactively →