Vacuole fusion

Across TCGA patient cohorts, RNA activity of the Vacuole fusion pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NUP155, RPS7, and RPS14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vacuole fusion activity versus NUP155 in PDAC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	NUP155 →	-0.110	-0.036	.003	<.001	3	5
GBM	RPS7 →	-0.280	-0.044	<.001	.003	2	5
PDAC	RPS14 →	-0.225	-0.031	<.001	<.001	3	4
UCEC	RSRC2_S4 →	-0.446	-0.072	.003	.009	2	5
LSCC	SUB1_S58 →	-0.381	-0.039	.003	.007	3	4
HNSC	SETD1A_S464 →	-0.356	-0.082	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097576 vs NUP155 — PDAC

Explore this scatter interactively →