Vacuole fusion

Across TCGA patient cohorts, RNA activity of the Vacuole fusion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGN2P32, PTAFR, and ITCH-AS1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vacuole fusion activity versus HMGN2P32 in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HMGN2P32 →	+0.212	+0.114	.001	.007	3	3
COAD	PTAFR →	-0.542	-0.105	.001	.008	3	3
PDAC	ITCH-AS1 →	+0.553	+0.199	<.001	<.001	3	3
COAD	DNAJB6P2 →	+0.147	+0.168	.001	.001	3	3
OV	NDUFS5P4 →	-0.259	-0.187	.006	.003	3	3
LUAD	C5 →	-0.826	-0.092	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097576 vs HMGN2P32 — BRCA

Explore this scatter interactively →