Vacuole fusion

Across TCGA patient cohorts, RNA activity of the Vacuole fusion pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF5B_S511, HTATSF1_S600, and SOX4_S348, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vacuole fusion activity versus EIF5B_S511 in LUAD (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EIF5B_S511 →	+0.724	+0.237	<.001	.001	3	3
OV	HTATSF1_S600 →	+1.042	+0.414	<.001	<.001	3	3
UCEC	SOX4_S348 →	+1.100	+0.193	<.001	.006	2	4
LUAD	SRRM2_T2034 →	+0.948	+0.192	.001	<.001	3	3
BRCA	CHMP2A_S203 →	+0.673	+0.195	<.001	<.001	2	4
OV	MAP1S_S731 →	-0.500	-0.217	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097576 vs EIF5B_S511 — LUAD

Explore this scatter interactively →