Vacuole fusion

Across TCGA cell cohorts, RNA activity of the Vacuole fusion pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MGAT3, VDAC2, and PBLD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MGAT3 grouped by Vacuole fusion-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MGAT3 →	-2.326	-1.921	.002	<.001	2	4
BREAST	VDAC2 →	-0.626	-0.437	<.001	.006	3	3
SOFT_TISSUE	PBLD →	-0.797	-1.822	.005	<.001	2	3
SOFT_TISSUE	PRSS27 →	-0.622	-1.273	.001	.008	3	2
SOFT_TISSUE	FUT2 →	-0.753	-1.522	.002	.004	3	2
SOFT_TISSUE	ACTRT3 →	-1.267	-1.058	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MGAT3 by Vacuole fusion activity — PANCREAS

Explore this box plot interactively →