Vacuole fusion

Across TCGA cell cohorts, RNA activity of the Vacuole fusion pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PI3, PEX7, and TCEANC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vacuole fusion activity versus PI3 in OESOPHAGUS (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PI3 →	-3.260	-0.953	.003	.003	3	5
BONE	PEX7 →	+1.006	+1.481	<.001	.001	3	5
BLOOD_Leukemia	TCEANC →	+0.430	+0.760	<.001	<.001	3	5
SKIN	UTP18 →	+0.600	+1.352	<.001	<.001	3	5
BLOOD_Leukemia	TERF2IP →	+0.522	+0.992	.001	<.001	3	5
LUNG_SCLC	HES6 →	+2.525	+0.709	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097576 vs PI3 — OESOPHAGUS

Explore this scatter interactively →