Mast cell migration

Across TCGA patient cohorts, RNA activity of the Mast cell migration pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYT5, SNAP25, and AMER3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mast cell migration activity versus SYT5 in GBM (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SYT5 →	+0.960	+0.253	<.001	.001	3	4
GBM	SNAP25 →	+2.154	+0.221	<.001	<.001	3	4
GBM	AMER3 →	+1.235	+0.239	<.001	<.001	3	4
PDAC	MARCHF4 →	+0.291	+0.367	.004	<.001	3	4
CCRCC	CTNNA2-AS1 →	-0.013	-0.568	.005	<.001	3	3
GBM	CACNA1B →	+0.971	+0.187	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097531 vs SYT5 — GBM

Explore this scatter interactively →