Mast cell migration

Across TCGA cell cohorts, RNA activity of the Mast cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VEGFD, PGF, and VEGFA, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VEGFD grouped by Mast cell migration-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	VEGFD →	-0.476	-1.405	.002	.009	3	9
PANCREAS	PGF →	-0.267	-1.284	<.001	<.001	3	7
LUNG_SCLC	VEGFA →	-0.303	-1.037	.001	.001	3	6
CNS	H2BU1 →	-0.322	-0.866	<.001	.001	3	5
SOFT_TISSUE	CHGA →	-0.363	-1.431	.003	.008	2	6
CNS	FXYD4 →	-0.302	-1.069	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VEGFD by Mast cell migration activity — SOFT_TISSUE

Explore this box plot interactively →