Mast cell migration

Across TCGA cell cohorts, RNA activity of the Mast cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC6A7, UBQLN2, and ZNF416, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC6A7 grouped by Mast cell migration-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC6A7 →	-0.205	-1.290	.003	<.001	3	4
LIVER	UBQLN2 →	-0.323	-1.639	.006	<.001	2	5
BREAST	ZNF416 →	-0.074	-0.678	.002	.002	3	3
BREAST	CLSPN →	+0.238	+1.046	.001	<.001	3	3
SKIN	TBX2 →	-0.227	-1.093	.002	.002	3	3
BREAST	PIK3CA →	-0.408	-0.594	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC6A7 by Mast cell migration activity — OVARY

Explore this box plot interactively →